In 1985, Stein et al, indentified an anaplastic large-cell malignant lymphoma that was distinctive because of the diffuse dermal infiltration of pleomorphic large lymphocytes, sinus growth pattern, and reactivity with the monoclonal antibody
Ki-1(CD30).
The clinical features distinguishing anaplastic large-cell Ki-1 lymphoma include a young median age, frequent peripheral adenopathy with sparing of the mediastinum, and extranodal disease with skin the most common site of involvement,
We report a case of Ki-1 positive large-cell lymphoma in a 74-year-old male patient who presented with multiple ulcerated nodules on the right shin area. (Kor J Dermatol 1993 ; 31(3) : 444-448)
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